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UNFRACTIONATED HEPARIN
Overall Structure:
Alternating residues of uronic acid & glucosamine that are variably sulfated.
Sulfation of residues in heparin is a major determinant of the anticoagulation activity of a given heparin preparation.
Mechanism of Action:
By itself heparin is not an anticoagulant.
Heparin binds allosterically to ANTITHROMBIN III to enhance inactivation of serine proteases (thrombin & factor Xa).
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LOW MOLECULAR WEIGHT HEPARIN
LMWH are isolated from commercial heparin preparations. They are more homgeneous than unfractionated haparin. They have higher specific activity.
LMW heparins have a ratio of antifactor Xa:antithrombin activity of 2:1 (heparin 1:1).
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Low Molecular Weight Heparins Currently Available:
ENOXAPARIN (LOVENOX)
DELTAPARIN (FRAGMIN)
TINZAPARIN (LOGIPARIN) |
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HEPARINOIDS
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