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Hematology Center
Heparins

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UNFRACTIONATED
Structure
Mechanism of Action
Dosing
-------------------
LOW MOLECULAR WEIGHT HEPARIN
Structure
Mechanism of Action
Dosing & Forms
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HEPARINOIDS
Structure
Mechanism of Action
Dosing & Forms

UNFRACTIONATED HEPARIN

Overall Structure:
Alternating residues of uronic acid & glucosamine that are variably sulfated.
Sulfation of residues in heparin is a major determinant of the anticoagulation activity of a given heparin preparation.

Mechanism of Action:
By itself heparin is not an anticoagulant.
Heparin binds allosterically to ANTITHROMBIN III to enhance inactivation of serine proteases (thrombin & factor Xa).

LOW MOLECULAR WEIGHT HEPARIN

LMWH are isolated from commercial heparin preparations. They are more homgeneous than unfractionated haparin. They have higher specific activity.
LMW heparins have a ratio of antifactor Xa:antithrombin activity of 2:1 (heparin 1:1).

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Low Molecular Weight Heparins Currently Available:

ENOXAPARIN (LOVENOX)

DELTAPARIN (FRAGMIN)

TINZAPARIN (LOGIPARIN)

HEPARINOIDS