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Antiemetics

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Should we treat or not???
Performace Status
Antiemetics
Growth Factors
Calculations
Chemo Precautions
Antidepressants
Chemoprotection
Hypercalcemia of malignancy
Mucositis
Neutropenia
Palliative Care
ALL
AML
Anal
Bladder Cancer
Brain Cancer
Breast (adjuvant)
Breast (metastatic)
Breast (hormonal)
Breast Cancer Genetics
Carcinoid
CLL
CML
COLON CANCER
CNS
Endometrial
Esophagous
Gastric
Gestational Trophoblastic Disease
Hairy Cell Leukemia
Head/Neck
Hodgkins
Islet Cell Tumors
Kidney
Liver
LUNG, NSC
Lung, SC
Lymphoma, Aggressive
Lymphoma, AIDS
Lymphoma, Burkitts
Lymphoma, CNS
Lymphoma, Cutaneous
Lymphoma, Indolent
Lymphoma, Mantle cell
Lymphoma, Mediastinal B-Cell
Lymphoma, Refractory NHL
Melanoma
Mesothelioma
Antiemetics
Multiple Myeloma
MDS
NHL
Ovarian
Pancreas
Prostate
Rectal Cancer
Sarcoma
Sarcoma, Osteogenic
Skeletal Metastasis
Testicular Cancer
Thymoma
Thyroid Cancer
Waldenstrom's
Unknown Primary
Molecular Genetics
Oncogenes, the list!
Immunoperoxidase stains
Tumor Markers
Bleomycin
Cisplatin
Etoposide
Ifosfamide
Methotrexate
Temazolamide
Mechanism of Action
Dose Modifications (Renal)
Dose Modifications (hepatic)

1. Serotonin antagonists:
--Ondasetron
--Granisetron
--Dolasetron
2. Dexamethasone
3. Metoclopramide
4. Dopaminergic Blockade:
--Haloperidol
--Droperidol
5. Benzodiazepines
--Lorazepam
6. Phenothiazides
--Prochlorperazine
7. Dronabinol

Dolasetron
100 mg PO
100 mg or 1.8 mg/kg IV

Granisetron
1 mg or 2 mg PO
1 mg or 0.01 mg IV

Ondasetron
16-24 mg PO X1 or 8 mg PO BID
8 mg or 0.15 mg/kg IV

Dexamethasone
20 mg PO
20 mg IV over 5 min

Metoclopramide
2-3 mg/kg Q 2-3 hr PO/IV

Haloperidol
1-2 mg PO Q4-6
1-3 mg IV Q4-6

Dronabinol
5 mg/m2 PO Q4 h

Prochlorperazine
10-20 mg IV Q3-4 h

Lorazepam
0.5-2.0 mg PO
0.5-3 mg IV Q4-6 h

Emetic Potentials:
HIGHEST:
--Cisplatin
HIGH:
--Carboplatin
--Carmustine
--Cyclophosphamide
--Cytarabine
--Dacarbazine
--Doxorubicin
--Epirubicin
--Hexamethylmelamine
--Idarubicin
--Ifosfamide
--Mechlorethamine
--Mitoxantrone
--Procarbazine
--Streptozocin
INTERMEDIATE:
--docetaxel
--Etoposide
--5FU
--Irinotecan
--Gemcitabine
--Methotrexate (>50 mg/m2)
--Mitomycin
--Paclitaxel
LOW:
--Bleomycin
--Busulfan
--Chlorambucil
--Fludarabine
--Hydroxyurea
--Methotrexate (<50 mg/m2)
--Melphalan
--Thioguaine
--Vinblastine
--Vincristine
--Vinorelbine

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