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Welcome to Dr. Hamid Sanatinia's Virtual Headquarters
Mesothelioma

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Should we treat or not???
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MDR

GEMZAR
GEMZAR + CISPLATIN
GEMZAR + CARBOPLATIN

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GEMZAR

GEMZAR 1250 mg/m2 DAYS 1,8,15

REPEAT Q 28 days

REF: Proc Am Soc Oncol 1998:17:A1784
Overall RR 31% (1 CR, 4 PR)

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GEMZAR + CISPLATIN

GEMZAR 1000 mg/m2 DAYS1,8, & 15
CISPLATIN 100 mg/m2 over 1 hours before gemzar on DAY 1

Repeat Q 28 days

REF: JCO 1999;17(1):25-30
Overall RR 47.6% (PR=47.6%);Median Survival ~41 weeks

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GEMZAR + CARBOPLATIN

GEMZAR 1000 mg/m2 DAYS 1, 8, 15
CARBOPLATIN AUC 5 DAY 1

REPEAT Q 28 days

REF: Ann Oncol 1998;9(suppl 4): A563P
overall RR= 16%
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