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Tumor Markers

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Molecular Genetics
Oncogenes, the list!
Immunoperoxidase stains
Tumor Markers
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Mechanism of Action
Dose Modifications (Renal)
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MDR

AFP
B-HCG
CA 19.9
CA 27.29
CA 125
CEA
LDH
Thyroglobulin



AFP
>>Produced by: Fetal Yolk Sac; Embryonic carcinoma elements of germ cell tumors.
>>Overall, AFP is NOT elevated in pure seminomas.
>>Half-life: 5 days


B-HCG
>>Produced by: Trophoblastic tissues; Syncytiotrophoblastic components of of germ cell tumors.
>>Overall, B-HCG is NOT elevated in seminomas. However, about 10% of cases may have low-level elevation of B-HCG.
>>beta-hCG is a marker for Gestational Trophoblastic Disease (GTD). However, it is not a reliable marker for Placental Site Trophoblastic Tumors (PST).
>>Half-life: 18-24 hours
>>There is some cross-reactivity in the radio-immunoassay with luteinizing hormone. Also, hCG can be falsely elevated in patients who use marijuana.

CA 19.9


CA 27.29


CA 125


CEA



LDH


Thyroglobulin