CLASS: Antitumor Antibiotic
SYNONYM: Blenoxane, bleo, BLE, BLM
EXTRAVASATION RISK: Can cause irritation or phlebitis
ROUTES OF ADMINISTRATION: IV, IM, SC, intrapleural injection
PRETREATMENT: consider pretreatment with tylenol or benadryl to reduce fevers
TEST DOSE: Give a test dose of 1-2 units for the first two doses and watch for anaphylaxis (keep anaphylaxis therapy at hand). Monitor vital signs before & for 3 minutes after the test dose. This is recommended for patients with lymphoma.
DRUG REACTIONS: May lower the serum concentrations of digoxin & phenytoin
RESPIRATORY: pneumonitis 10%, life-threatening pulmonary fibrosis 1%, Toxicity may occur when cumulative doses>400 mg when risk factors are present. RISK FACTORS- age, XRT to lungs, recent cisplatin therapy, O2 therapy during or after bleomycin, declining renal function.
HYPERSENSITIVITY: Anaphylaxis could occur to 1% of lymphoma patients.
GASTROINTESTINAL: Low potential for N/V
CARDIOVASCULAR: MI, CVA, thrombotic microangiopathy, Raynaud's
MISC: Fevers & chills