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Temazolamide

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Temazolamide
Mechanism of Action
Dose Modifications (Renal)
Dose Modifications (hepatic)
MDR

Temodar (Temazolamide)

Oral alkylating agent

Starting dose: 150 mg/m2/day for 5 days on a 28-day cycle.
Next cycle: Adjust dose according to nadir neutrophil & platelet counts in the previous cycle & at the start of each cycle.
Nadir usually occurs around day 22
Patients take temodar for a maximum of 2 years, or until disease progression or intolerable side effects occur.
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Dose modification:
Based on lowest counts at either Day 22 or Day 29:
1. ANC<1,000 or PLT<50,000 - postpone therapy until ANC>1500 & PLT<100,000. Reduce dose by 50 mg/m2/d for subsequent cycle.
2. ANC 1000-1500 or PLT 50000-100000 - Postpone therapy until ANC>1500 & PLT<100,000. Maintain initial dose.
3. . ANC>1,500 or PLT>100,000 - Increase dose to or maintain dose at 200 mg/m2 X 5 days for subsequent cycle.
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Side Effects
Myelosuppression
Nausea & vomiting mild to moderate
Fatigue mild to moderate
Constipation, Headache, Diarrhea