|
Coagulation abnormalities
Progressive loss of liver parenchymal cells in chronic liver disease is associated with decrease in the levels of all coagulation factors except factor VIII.
|  |
|
DIC
A low-grade DIC or localized intravascular coagulation may occur in association with severe liver disease. Overt DIC as a cause of bleeding is rare in the absence of other etiologies.
|
| |
|
Fibrinogenolysis & Fibrinolysis
Endogenous plasminogen activators are usually cleared by the liver. In severe liver disease, they may circulate for a long time leading to chronic or intermittent activation of fibrinolytic enzyme system. This is not generally of clinical importance unless other stress factors induce acute fibrinolysis (ie surgery, trauma, drugs, etc). This may contribute to hypofibrinogenemia and increased amounts of FDPs. It may also impair platelet function and blood coagulation.
AT-III, antiplasmin, plasminogen levels: Subnormal in liver disease
|
|
|
|
