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Hematology Center
Liver and hemostasis

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Bleeding Patient
Reversing Coumadin
Reversing Heparin
Laboratory Tests in Hematology
Laboratory Tests In Coagulation
Aceruloplasminemia
African Iron Overload
Anemia, microcytic
Antiphospholipid Syndrome
Anemia, Microcytic, real cases
ATIII Deficiency
Atransferrinemia
Aplastic Anemia
B12 deficiency
Basophilia
Coagulation and Cancer
DIC
Essential Thrombocytosis
ENZYME DISORDERS (RBC)
Eosinophilia
Folate Deficiency
Hemoglobinoapthies
Hemoglobin S/C
Hemoglobin S/S
Hemolytic Anemia
Hemochromatosis
Hemophilia
Hemostasis
Heparins
Heparin-induced thrombocytopenia
Hypercoagulable States
Hyper-Ferritinemia
ITP
Iron Chelation
IRON DEFICIENCY
IRON OVERLOAD
IRON STUDIES
Liver and hemostasis
Megaloblastic Anemia
Monocytosis
Myleofibrosis with Myeloid Metaplasia
Neutrophil Structure
vWF
Porphyria
Phorphyrias (AIP)
Phorphyrias (AIP)
Polycythemia Vera
Prothrombin 20210A
RBC Membrane Disorders
Sickle Cell
Sideroblastic Anemias
Syndromes
TTP
Thalassemia
Thrombocytopenia, congenital
Wilson's Disease
Immunological markers
Amicar
Anagrelide
Oral Anticoagulants
Refludan

Prothrombin Time
Coagulation system abnormalities
DIC in liver disease
Firbinolysis in liver disease

Coagulation abnormalities

Progressive loss of liver parenchymal cells in chronic liver disease is associated with decrease in the levels of all coagulation factors except factor VIII.

DIC
A low-grade DIC or localized intravascular coagulation may occur in association with severe liver disease. Overt DIC as a cause of bleeding is rare in the absence of other etiologies.

Fibrinogenolysis & Fibrinolysis

Endogenous plasminogen activators are usually cleared by the liver. In severe liver disease, they may circulate for a long time leading to chronic or intermittent activation of fibrinolytic enzyme system. This is not generally of clinical importance unless other stress factors induce acute fibrinolysis (ie surgery, trauma, drugs, etc). This may contribute to hypofibrinogenemia and increased amounts of FDPs. It may also impair platelet function and blood coagulation.
AT-III, antiplasmin, plasminogen levels: Subnormal in liver disease