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Bleeding Patient
Reversing Coumadin
Reversing Heparin
Laboratory Tests in Hematology
Laboratory Tests In Coagulation
Aceruloplasminemia
African Iron Overload
Anemia, microcytic
Antiphospholipid Syndrome
Anemia, Microcytic, real cases
ATIII Deficiency
Atransferrinemia
Aplastic Anemia
B12 deficiency
Basophilia
Coagulation and Cancer
DIC
Essential Thrombocytosis
ENZYME DISORDERS (RBC)
Eosinophilia
Folate Deficiency
Hemoglobinoapthies
Hemoglobin S/C
Hemoglobin S/S
Hemolytic Anemia
Hemochromatosis
Hemophilia
Hemostasis
Heparins
Heparin-induced thrombocytopenia
Hypercoagulable States
Hyper-Ferritinemia
ITP
Iron Chelation
IRON DEFICIENCY
IRON OVERLOAD
IRON STUDIES
Liver and hemostasis
Megaloblastic Anemia
Monocytosis
Myleofibrosis with Myeloid Metaplasia
Neutrophil Structure
vWF
Porphyria
Phorphyrias (AIP)
Phorphyrias (AIP)
Polycythemia Vera
Prothrombin 20210A
RBC Membrane Disorders
Sickle Cell
Sideroblastic Anemias
Syndromes
TTP
Thalassemia
Thrombocytopenia, congenital
Wilson's Disease
Immunological markers
Amicar
Anagrelide
Oral Anticoagulants
Refludan
Hematology Center
IRON STUDIES


IRON COMPARTMENTALIZATION
1. OPERATIONAL IRON:
Heme attached to either hemoglobin, myoglobin, cytochromes, peroxidases, and catalases.
Heme is formed by attaching a ferrous iron atom (Fe2+) into protoporphyrin IX.
Each Hgb molecule has about 0.35% iron. This is means that 1 ml of PRBC contains about 1 mg of elemental iron.

2. STORAGE IRON
The second largest iron compartment.
Most are found in the hepatocytes. Other prominent sites include macrophages in the bone marrow, liver, and spleen.
FERRITIN- Iron is deposited in ferritin. Ferritin sequesters iron from the rest of the cell therefore preventing damage from uncontrolled oxidation.
HEMOSIDERIN- Ferritin is slowly proteolyzed within lysosomes to a non-specific complex containing iron, partially degraded protein, & lipid. This material is called hemosiderin. Hemosiderin is prominent in cells heavily loaded with iron. Hemosiderin appears to be the dead end in the metabolism of iron & ferritin. The only way the iron could be leached out of this complex is when high concentration of chelators are present.

3. LABILE IRON

4. TRANSPORT IRON