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INHERITED DISORDERS
Activated Protein C Resistance (Factor V leiden)
Protein C deficiency
Protein S deficiency
Thrombomodulin deficiency
ATIII deficiency
Prothrombin mutation
Dysfibrinogenemia
Plasminogen deficiency
t-PA deficiency
Excess PAI-1 activity
Homocysteinemia
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ACQUIRED DISORDERS
Vascular Disorders
Abnormal Rheology
Platelet Dysfunction
Others:
1. Cancer
2. Oral contraceptives
3. Estrogen therapy
4. Pregnancy
5. Infusion of prothrombin complexes
6. Nephrotic Syndrome
7. TTP
8. DIC
9. antiphospholipid syndrome
10. Heparin-induced thrombocytopenia
11. Antibodies to calpastatin |
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Misc
Lab tests that are useless if patient is on Warfarin:
1. Protein C & S functional assays (remember both are vitamin K-dependent factors)
2. ATIII
Lab tests that are useless if patient is on Heparin:
ATIII
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