____________________________________________________________ Single Agent Chemotherapy 5FU Doxorubicin IFN-alpha 2a IFN-aplpha 2b Response rates with these agents are in the range of 10-20%, responses are <6 months in duration, & complete remissions are rare! Combination Chemotherapy Only marginal efficacy vs single agents! ____________________________________________________________ Treatment of Symptoms Somatostatin analogues OCTREOTIDE ACETATE (SANDOSTATIN) 100-600 ug/d SC/IV in 2-4 divided doses (titrate to symptoms) For diarrhea associated with VIPomas: 200-300 ug/day SC/IV in 2-4 divided doses Side effects: Chronic treatment may be associated with cholelithiasis, increased fecal fat excretion, fluid retention, nausea, & glucose intolerance. Occasional objective responses have been observed in patients who have received octreotide. ------------------------------------------------------------ LONG-ACTING OCTREOTIDE SANDOSTATIN LAR Monthly injections
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