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Growth Factors

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Oncogenes, the list!
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Mechanism of Action
Dose Modifications (Renal)
Dose Modifications (hepatic)
MDR

Leukine
Neumega
Neupogen
Procrit
Aranesp (darbepoetin alfa)
Neulasta

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LEUKINE (rGM-CSF SARGRAMOSTIN)

250 ug/m2/day IV or SQ

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NEUMEGA (OPRELVEKIN)

50 ug/kg given once daily. Initiate dosing 6-24 hours after the completion of chemotherapy & discontinue at least 2 days before starting the next planned cycle. Give Neumega for 10 days or until plts recover to >50,000 but not for more than 21 days.
Caution: Fluid retention. Watch or avoid in diabetes or CHF patients.

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NEUPOGEN (rG-CSF)

5 ug/kg/day
BMT patients or PBPC mobilization: 10 ug/kg/day

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PROCRIT (EPOETIN ALFA)

150 U/Kg SQ 3x/week

40,000 U/Kg SQ Qweek
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Aranesp (darbepoetin alfa)

200 ug sq every other week

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