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Welcome to Dr. Hamid Sanatinia's Virtual Headquarters
Mechanism of Action

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Should we treat or not???
Performace Status
Antiemetics
Growth Factors
Calculations
Chemo Precautions
TOXICITY CRITERIA
Antidepressants
Chemoprotection
MESNA
Dexrazoxane
Radioprotectants
Hypercalcemia of malignancy
Mucositis
Neutropenic Fever
Palliative Care
Radiation Oncology
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ALL
AML
Anal
Bladder Cancer
Brain Cancer
Breast (risk category)
Breast (adjuvant)
Breast (metastatic)
Breast (Xeloda)
Breast (hormonal)
Breast Cancer Genetics
Carcinoid
CLL
CML
COLON CANCER
Endometrial
Esophagous
Gastric
Gestational Trophoblastic Disease
Germ Cell (Ovary)
Hairy Cell Leukemia
Head/Neck
Head/Neck: ChemoRT abstracts
Head/Neck: Larynx
Head/Neck:Nasopharyngeal
Hodgkins
Islet Cell Tumors
Kidney
Liver
LUNG, NSC
Stage III Unresectable NSC Lung Cancer
Lung, SC
Lymphoma, Aggressive
Lymphoma, AIDS
Lymphoma, Burkitts
Lymphoma, CNS
Lymphoma, Cutaneous
Lymphoma, Indolent
Lymphoma, MALT
Lymphoma, Mantle cell
Lymphoma, Mediastinal B-Cell
Lymphoma, Refractory NHL
Melanoma
Mesothelioma
Multiple Myeloma
MDS
NHL
Ovarian
Pancreas
Prostate
Prostate (Hormonal)
Rectal Cancer
Sarcoma
Sarcoma, Ewing's
Sarcoma, Osteogenic
Skeletal Metastasis
Testicular Cancer
Thymoma
Thyroid Cancer
Waldenstrom's
Unknown Primary
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Molecular Genetics
Oncogenes, the list!
Immunoperoxidase stains
Tumor Markers
Bleomycin
Cisplatin
Etoposide
Ifosfamide
Methotrexate
Temazolamide
Mechanism of Action
Dose Modifications (Renal)
Dose Modifications (hepatic)
MDR

Drug--->Mechanism of Action
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1. CISPLATIN/CARBOPLATIN---->cross-links DNA, interstrand or intrastrand
2. TAXOL/TAXOTERE--> enhances tubulin polymerization (high affinity binding for microtubules)
3. VINCA ALKALOIDS (VINCRISTINE; VINBLASTINE; VINORELBINE)--> binds to specific sites on tubulin & prevents polymerization of tubulin dimers & inhibits microtubule formation. Note that vinorelbine does not affect neural microtubules as much as the other vinca alkaloids (less neurotoxicity).
4. ANTHRACYCLINES--> Free radical formation; topoisomerase II-mediated DNA damage; direct intercalation into DNA
5. EPIPODOPHYLLOTOXINS (VP-16; VM-26)-->inhibits the function of topoisomerase II. Results in single strand DNA breasks
6. CAMPTOTHECIN (Irinotecan; topotecan)--> Interact non-covalently with topoisomerase I & inhibit the religation step.
7. ALKYLATING AGENTS
8. BLEOMYCIN-->produces single/double stranded DNA breaks. Requires activation by oxidized iron.